Intermittent Fasting Works, Helps at Least in the Short Term

Dec. 23, 2021 — Intermittent fasting can lead to weight loss and other health benefits, at least in the short-term, new research suggests.

Combined results from a total of 130 clinical trials show that intermittent fasting could help reduce weight, body mass index (BMI), body fat, “bad” cholesterol, fasting blood sugar, and blood pressure, among other risk factors associated with obesity.

Two specific types of intermittent fasting were associated with significant weight loss and other health benefits. One, called modified alternate-day fasting, involves alternating one day of eating as usual with consuming no more than 600 the next day.

The other, called the “5:2 Diet” is similar, but involves 2 days per week of zero or very low-calorie eating and 5 days of normal eating.

Less beneficial were time-restricted eating, involving fasting 12-24 hours per day, and “zero calorie alternate-day fasting,” where no food is consumed every other day.

“Our results support the role of intermittent fasting, especially modified alternate-day fasting, in adults with overweight or obesity as a weight loss approach with other health benefits. But individuals have to consult their doctors first,” lead author of the research, Chanthawat Patikorn, of Chulalongkorn University in Thailand says.

And there’s a major snag: most of the studies lasted only about 3 months.

Among those lasting longer, the weight loss seemed to level off by about 6 months, either because the body adapted to the eating pattern or because the participants couldn’t stick to the diets.

“We are still lacking data to see if these could work in the long-term. We see weight loss and improved metabolic profiles but we still don’t know if intermittent fasting can lead to reduced death or cardiovascular events,” Patikorn says.

On the other hand, “I would say that if the patient is interested in doing intermittent fasting, there is no evidence that it’s a bad thing.”

He did caution, however, that patterns where you consume nothing for long periods of time could pose a danger for people with diabetes who use insulin or are otherwise prone to low blood sugar (hypoglycemia).